Inflammation And Infection
You may often hear the words infection and inflammation together, but they mean very different things. Infection refers to the invasion and multiplication of a pathogen within the body, while inflammation is caused by a number of physical reactions triggered by the immune system in response to a physical injury or an infection. Inflammation does not necessarily mean that there is an infection, but an infection can cause inflammation.
Inflammation is part of the complex biological response of body tissues to harmful stimuli, such as pathogens, damaged cells, or irritants,and is a protective response involving immune cells, blood vessels, and molecular mediators. The five classical signs of inflammation are heat, pain, redness, swelling, and loss of function. There are generally two types of inflammation: acute and chronic inflammation. Tissue damage due to trauma, microbial invasion, or noxious compounds all induce acute inflammation. It starts rapidly, becomes severe in a short time and symptoms may last for a few days. Chronic inflammation is also referred to as slow, long-term inflammation lasting for prolonged periods of several months to many years.
Infection refers to the invasion and multiplication of a pathogen within the body. An infection occurs when another organism enters your body and causes disease. The organisms that cause infections are very diverse and can include things like viruses, bacteria, fungi, and parasites. Most pathogens causing infectious diseases are transmissible, you can acquire an infection in many different ways, such as directly from a person with an infection, via contaminated food or water, and even through the bite of an insect.
Chronic inflammation can form various lesions that are not easy to cure, such as blockages, calcifications, fibrosis, granuloma, ulcers, etc. Long-term chronic inflammation can cause serious health problems, such as cardiovascular disease, chronic lung diseases (including asthma) , diabetes, and cancer. Chronic inflammation-related chronic diseases are the most significant cause of death in the world. Worldwide, 3 of 5 people die due to inflammation-related chronic diseases like stroke, chronic respiratory diseases, heart disorders, cancer, obesity , and diabetes. Globally, new causes of communicable infection are always emerging, some examples you may be familiar with include severe acute respiratory syndrome (SARS) and Corona Virus Disease 2019，COVID-19. When a global infectious disease breaks out,the dead people are mainly concentrated in these patients with inflammation-related chronic diseases.
Symptoms of Chronic Inflammation
Some of the common signs and symptoms that develop during chronic inflammation are listed below.
Body pain
Weight gain
Frequent infections
Constant fatigue and insomnia
Depression, anxiety and mood disorders
Gastrointestinal complications like constipation and diarrhea.
The Causes of Chronic Inflammation
Chronic inflammatory diseases are usually caused by bacterial biofilm, inflammatory factors, and toxic compounds.
Bacterial biofilm is an architectural colony of microorganisms. In general, bacterial biofilms show resistance against human immune system, as well as against antibiotics. The process of biofilm formation consists of many steps, starting with attachment to a living or non-living surface that will lead to formation of micro-colony, giving rise to three-dimensional structures and ending up, after maturation, with detachment. The colonies include free bacteria that can be shed from the surface of the biofilm and fixed bacteria that root in the deep layer of the biofilm and can survive for a long time. Due to the use of antibiotics and the adoption of various social measures, acute inflammations caused by free bacteria that can be shed from the surface of the biofilm can be controlled relatively quickly. However,chronic inflammations caused by fixed bacteria rooted in the deep layer of the biofilm that can survive for a long time are gradually increasing, especially in people with reduced resistance due to various toxic compounds. Fixed bacteria rooted in the deep layer of the biofilm that can survive for a long time have natural resistance to antibiotics and body immunity, and it is difficult to completely remove them with antibiotics. Antibiotics can only kill free pathogens on the surface of the biofilm or in the blood that cause the onset of infection. When the body’s resistance drops, fixed bacteria rooted in the deep layer of the biofilm that can survive for a long time can be released again and cause infection again. The biofilm is like a “bacterial nest”, causing repeated infections, prolonged unhealed, and chronic inflammations.
The biofilm pathogens, and toxic compounds can stimulate the body to produce many pathogenic factors, including inflammatory cytokines (such as TNF-α, IL-1, IL-6, IL-8, etc.) and inflammatory mediators (such as group amines , bradykinin, prostaglandins, oxygen free radicals and lysosomal enzymes, etc.). These inflammatory factors damages normal tissue cells and plays an important role in the development of chronic inflammatory diseases.
Toxic compounds refers to harmful chemicals in the human body.
Toxic compounds is divided into exotoxin and endotoxin. Exotoxin refers to environment pollution brings harmful chemicals, such as, air pollution, water pollution, and food pollution. Endotoxin refers to harmful chemicals created in the human body during the process of metabolism. These harmful chemicals include lactic acid, ketone acid, uric acid, and free radicals. Toxic compounds also includes biological toxins produced by pathogens, excess fat, advanced glycation end products (AGEs), and old and dead cells in the human body.
When you have chronic inflammation, your body’s inflammatory response and the endotoxins produced can eventually start damaging healthy cells, tissues, and organs. Over time, this can lead to DNA damage, tissue cells death, and internal scarring. Chronic inflammation can form various diseased areas that are not easy to cure, such as blockages, calcifications, fibrosis, granuloma, ulcers, etc. All of these are linked to the development of some complex chronic diseases, including cancer, heart disease, rheumatoid arthritis, type 2 diabetes, obesity , asthma, neurodegenerative diseases, such as Alzheimer’s disease. Chronic inflammatory diseases are the most significant factors of death in the world.
Risk Factors Associated with Chronic Inflammation
Several risk factors promote low-level inflammatory response. These include:
Age: Increasing age is positively correlated with elevated levels of several inflammatory molecules. The age-associated increase in inflammatory molecules may be due to mitochondrial dysfunction or free radical accumulation over time and other age-related factors like increase in visceral body fat.
Obesity: Many studies reported that fat tissue is an endocrine organ, secreting multiple adipokines and other inflammatory mediators. Some reports show that body mass index of an individual is proportional to the amount of pro-inflammatory cytokines secreted. Metabolic syndrome typifies this well .
Diet: Diet rich in saturated fat, trans-fats, or refined sugar is associated with higher production of pro-inflammatory molecules, especially in individuals with diabetes or overweight individuals.
Smoking: Cigarette smoking is associated with lowering the production of anti-inflammatory molecules and inducing inflammation.
Low Sex Hormones: Studies show that sex hormones like testosterone and estrogen can suppress the production and secretion of several pro-inflammatory markers and it has been observed that maintaining sex hormone levels reduces the risk of several inflammatory diseases.
Stress and Sleep Disorders: Both physical and emotional stress is associated with inflammatory cytokine release. Stress can also cause sleep disorders. Since individuals with irregular sleep schedules are more likely to have chronic inflammation than consistent sleepers.
Complications of Chronic Inflammation
Although chronic inflammation progresses silently, it is the cause of most chronic diseases and presents a major threat to the health and longevity of individuals. Inflammation is considered a major contributor to several diseases.
1) Cardiovascular diseases: Many clinical studies have shown strong and consistent relationships between markers of inflammation such as hsCRP and cardiovascular disease prediction. Furthermore, Atherosclerosis is a pro-inflammatory state with all the features of chronic low-grade inflammation and leads to increase cardiovascular events such as myocardial infarction, stroke, among others.
2) Cancer: Chronic low-level inflammation also appears to participate in many types of cancer such as kidney, prostate, ovarian, hepatocellular, pancreatic, colorectal, lung, and mesothelioma.
3) Diabetes: Immune cells like macrophages infiltrate pancreatic tissues releasing pro-inflammatory molecules in diabetic individuals. Both are circulating and cellular biomarkers underscore that diabetes is a chronic inflammatory disease. Chronic complications linked with diabetes include both microvascular and macrovascular complications. Diabetes not only increases the risk of macrovascular complications like strokes and heart attacks but also the microvascular complications like diabetic retinopathy, neuropathy, and nephropathy.
4) Rheumatoid arthritis: It is thought to be initiated by an infectious agent or an environmental factor like exposure to cigarette smoke which induces a local inflammatory response in joints, infiltration of immune cells and release of cytokines.
Allergic asthma: A complex, chronic inflammatory disorder associated with inappropriate immune response and inflammation in conducting airways involving a decline in airway function and tissue remodeling.
5) Chronic obstructive pulmonary disease (COPD): An obstructive lung disease, develops as a chronic inflammatory response to inspired irritants and characterized by long-term breathing problems.
6) Alzheimer: In older adults, chronic low-level inflammation is linked to cognitive decline and dementia.
7) Chronic kidney disease (CKD): Low-grade inflammation is a common feature of chronic kidney disease. It can lead to the retention of several pro-inflammatory molecules in the blood and contributes to the progression of CKD and mortality.
8) Inflammatory Bowel Disease (IBD) is a group of chronic inflammatory disorders of the digestive tract. It can develop as ulcerative colitis causing long-lasting inflammation and ulcers in the lining of large intestine and rectum or Crohn’s disease characterized by inflammation of the lining of digestive tract dispersing into affected tissues such as mouth, esophagus, stomach and the anus.
Tests for Chronic Inflammation
Unfortunately, there are no highly effective laboratory measures to assess patients for chronic inflammation and diagnoses are only undertaken when the inflammation occurs in association with another medical condition.
The two blood tests that are inexpensive and good markers of systemic inflammation include high-sensitivity C-reactive protein (hsCRP) and fibrinogen. High levels of hs-CRP indicate inflammation, but it is not a specific marker for chronic inflammation since it is also elevated in acute inflammation resulting from a recent injury or sickness.
Detecting pro-inflammatory cytokines like tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1beta), interleukin-6 (IL-6), and interleukin-8 (IL-8) is an expensive method but may identify specific factors causing chronic inflammation. Again, the assays are not standardized like hs-CRP, fibrinogen, and SPE.
The best test to confirm clinically chronic inflammation is serum protein electrophoresis (SPE) which shows concomitant hypoalbuminemia and polyclonal increase in all gamma globulins (polyclonal gammopathy).
3D Inflammation Precise Therapy Successfully Treat various Chronic Inflammatory Diseases
3D Inflammation Precise Therapy is an advanced method to effectively prevent and treat various types of chronic inflammatory diseases without any side effects. Most therapeutic medicines are natural targeted extracts with no side effects and no drug resistance. Natural targeted extracts can target inflammation diseased areas at multiple sites and multiple targets，and allow effective ingredients to accumulate in the targeted inflammation diseased areas and form a higher therapeutic concentration. 3D Inflammation Precise Therapy treats the root factors of chronic inflammatory diseases. Once cured, the patient’s disease will not easily relapse.
3D Inflammation Precise Therapy medicines are th powerful natural targeted extracts combined with a proprietary detoxing formula. The powerful anti-inflammatory natural targeted extracts combined with a proprietary detoxing formula can destroy bacterial biofilm and inflammatory factors, discharge toxic compounds, and successfully treats various chronic inflammatory diseases.
Patients who receive our treatments say they did not experience any significant discomfort. Their energy level, appetite, and sleep quality improve greatly. Also, they were able to see toxic compounds being discharged in their urine during the treatment. Generally, the symptoms improved obviously after 3 weeks of treatment. Receiving 3-6 months treatment can eradicate the root causes of chronic inflammation.
Our 3D Precise Therapy is a scientific and natural therapy. It is highly efficient, safe, has short treatment periods, a consolidated cure effect, no significant pain, and no negative side effects. Patients who receive our 3D Precise Therapy come to understand that our techniques, skills, and clinical experience are the best in the world. No other doctors or medical establishments in the world have achieved our high success rates.
3D Inflammation Targeted Therapy is suitable for various chronic inflammatory diseases, including rhinitis, sinusitis, otitis media, pharyngitis, gastritis, hepatitis, enteritis, urethritis, prostatitis, rheumatoid arthritis, cervicitis, periodontitis, acne, etc.
90%
The cure rate of 3D chronic inflammatory diseases treatment can reach 90%, while the traditional chronic inflammatory diseases treatment, their cure rate is less than 20%.
Chronic Inflammation Traditional Treatment
There are many chronic inflammatory disorders with no cure. Most are managed with symptomatic therapy. The trigger factors need to be controlled and in some cases, lifestyle may need to be modified. Unfortunately in some cases, one may need life long anti-inflammatory medications to control symptoms.
At present, all traditional anti-inflammatory drugs only treat the symptoms of inflammation, not the root cause of inflammation. They cannot destroy the bacterial biofilm, let alone discharge toxic compounds, so after treatment, chronic inflammation can easily recur. In addition, traditional anti-inflammatory drugs have huge side effects, and patients cannot use them for a long time.
Traditional anti-inflammatory drugs mainly include non-steroidal anti-inflammatory drugs (NSAIDs) and steroidal anti-inflammatory drugs(corticosteroids), and antibiotics.
Common side effects of NSAIDs include: stomach pain and heartburn, stomach ulcers, diarrhea and/or constipationa, tendency to bleed more, headaches and dizziness, ringing in the ears, allergic reactions, liver or kidney problems, high blood pressure,etc.
Common side effects of corticosteroids include: weight gain or swelling of the legs (edema), High blood pressure.Loss of potassium. Headache. Muscle weakness.Puffiness of the face (moon face), Facial hair growth.Thinning and easy bruising of the skin,etc.
The most common side effects of antibiotics affect the digestive system, allergic reactions, and damage to liver and kidney functions.
Minimizing the Effects of Chronic Inflammation
Many dietary and lifestyle changes may be helpful in removing inflammation triggers and reducing chronic inflammation as listed below. The most effective is weight loss.
1) Low-glycemic diet: Diet with a high glycemic index is related to high risk of stroke, coronary heart disease, and type 2 diabetes mellitus. It is beneficial to limit consumption of inflammation-promoting foods like sodas, refined carbohydrates, fructose corn syrup in a diet.
2) Reduce intake of total, saturated fat and trans fats: Some dietary saturated and synthetic trans-fats aggravate inflammation, while omega-3 polyunsaturated fats appear to be anti-inflammatory. Processed and packaged foods that contain trans fats such as processed seed and vegetable oils, baked goods (like soybean and corn oil) should be reduced from the diet.
3) Fruits and vegetables: Blueberries, apples, Brussels sprouts, cabbage, broccoli, and cauliflower, that are high in natural antioxidants and polyphenols and other anti-inflammatory compounds, may protect against inflammation.
4) Fiber: High intake of dietary soluble and insoluble fiber is associated with lowering levels of IL-6 and TNF-alpha.
5) Nuts: such as almonds is associated with lowering risk of cardiovascular disease and diabetes.
6) Green and black tea polyphenols: Tea polyphenols are associated with a reduction in CRP in human clinical studies.
7) Curcumin: a constituent of turmeric causes significant patient improvements in several inflammatory diseases especially in animal models.
8) Fish Oil: The richest source of the omega-3 fatty acids. Higher intake of omega-3 fatty acids is associated with lowering levels of TNF-alpha, CRP, and IL-6.
9) Mung bean: Rich in flavonoids (particularly vitexin and isovitexin). It is traditional food and herbal medicine known for its anti-inflammatory effects.
10) Micronutrients: Magnesium, vitamin D, vitamin E, zinc and selenium).
11) Physical Exercise: In human clinical trials, it is shown that energy expenditure through exercise lowers multiple pro-inflammatory molecules and cytokines independently of weight loss.